Microfluidic Immunoaffinity Basophil Activation Test for Point-of-Care Allergy Diagnosis
نویسندگان
چکیده
منابع مشابه
Is basophil activation test (BAT) really useful for allergy diagnosis?
Dear Editor, both the paper by Pereira Santos et al and the Editorial on the latest issue of this Journal, stressed on the essential, fairly irreplaceable role of basophil activation test (BAT) in allergy diagnosis (1,2). Certainly, BAT is a cell-based test and in this sense it should give fundamental insights about the role of these circulating leukocytes in hypersensitivity reactions, chronic...
متن کامل[Basophil activation test in the diagnosis of allergy to medicines].
In this paper we study the reliability of the basophil activation test (BAT) in the "in-vitro" diagnosis of allergy to betalactams and to metamizol, and the sensitivity and specificity of the technique are analyzed. To this end, we studied 58 patients allergic to betalactam antibiotics with a positive cutaneous test facing any derivative of penicillin and 30 healthy controls who tolerated betal...
متن کاملBasophil activation test: handle with care.
The letter to the Editor by Dr Chirumbolo highlights the major pitfalls in basophil activation test (BAT) performance. In my view, basophil activation test should be considered as an additional clinical tool in the diagnosis of allergy and not the “absolute truth”. Basophils play a pivotal role as effector cells in allergic disease, despite representing a small population of peripheral leucocyt...
متن کاملBasophil Markers for Identification and Activation in the Indirect Basophil Activation Test by Flow Cytometry for Diagnosis of Autoimmune Urticaria
BACKGROUND The indirect basophil activation test using flow cytometry is a promising tool for autoimmune urticaria diagnosis. We aimed to identify better donor basophils (from atopic vs. non-atopic donors and interleukin-3 primed vs. unprimed basophils) and improve basophil identification and activation markers (eotaxin CC chemokine receptor-3 [CCR3] vs. CD123 and CD63 vs. CD203c). METHODS Do...
متن کاملRoad map for the clinical application of the basophil activation test in food allergy
The diagnosis of IgE-mediated food allergy based solely on the clinical history and the documentation of specific IgE to whole allergen extract or single allergens is often ambiguous, requiring oral food challenges (OFCs), with the attendant risk and inconvenience to the patient, to confirm the diagnosis of food allergy. This is a considerable proportion of patients assessed in allergy clinics....
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ژورنال
عنوان ژورنال: The Journal of Applied Laboratory Medicine
سال: 2019
ISSN: 2576-9456,2475-7241
DOI: 10.1373/jalm.2018.026641